| Player | Team | 2B |
|---|---|---|
| German Marquez | Clinton | 61 |
| Zack Wheeler | Brooklyn | 51 |
| Logan Webb | Amarillo | 51 |
| Rick Porcello | Phoenix | 50 |
| Patrick Corbin | Brooklyn | 48 |
| Kyle Freeland | Monet | 48 |
| Antonio Senzatela | El Paso | 48 |
| Anibal Sanchez | Wisc. Rapids | 46 |
| Chris Bassitt | Chicago | 44 |
| Adrian Houser | Chicago | 43 |
| Martin Perez | Chicago | 43 |
| Tyler Anderson | Monet | 42 |
| Lance Lynn | Brooklyn | 41 |
| Hyun Jin Ryu | Wisc. Rapids | 41 |
| Zack Greinke | Wisc. Rapids | 41 |
| Randy Dobnak | Oak Lawn | 40 |
| Aaron Civale | El Paso | 40 |
| Nathan Eovaldi | El Paso | 40 |
| Garrett Richards | Torrance Beach | 40 |
| Jake Odorizzi | Amarillo | 40 |