| Player | Team | R |
|---|---|---|
| Jordan Lyles | Kankakee | 156 |
| Jake Odorizzi | Herefordshire | 143 |
| Patrick Corbin | Portland | 134 |
| Lance Lynn | Pea Ridge | 132 |
| Griffin Canning | Orlando | 127 |
| Zac Gallen | Orlando | 121 |
| Blake Snell | Orlando | 120 |
| James Paxton | Ohio | 120 |
| Brett Anderson | Orlando | 118 |
| Trevor Rogers | Herefordshire | 118 |
| Tanner Roark | Herefordshire | 116 |
| Antonio Senzatela | Pea Ridge | 116 |
| Justus Sheffield | South Iowa | 115 |
| Logan Webb | Albuquerque | 115 |
| Mike Fiers | Dakota | 113 |
| Andrew Heaney | Boise | 113 |
| Jake Arrieta | Albuquerque | 112 |
| Tyler Anderson | South Iowa | 108 |
| Nathan Eovaldi | Portland | 105 |
| Luis Castillo | Dakota | 105 |