| Player | Team | W |
|---|---|---|
| Yu Darvish | Boise | 19 |
| Shane Bieber | Kankakee | 18 |
| Zack Greinke | Albuquerque | 17 |
| Brandon Woodruff | Portland | 16 |
| Andrew Heaney | Boise | 16 |
| Jose Berrios | Ohio | 16 |
| Trevor Bauer | Ohio | 16 |
| Aaron Nola | Portland | 15 |
| Kevin Gausman | Kankakee | 14 |
| Tyler Glasnow | Dakota | 14 |
| Luis Castillo | Dakota | 14 |
| Lance Lynn | Pea Ridge | 14 |
| Hyun Jin Ryu | Pea Ridge | 13 |
| Zach Eflin | Herefordshire | 13 |
| Antonio Senzatela | Pea Ridge | 13 |
| Dallas Keuchel | South Iowa | 13 |
| James Paxton | Ohio | 12 |
| Zac Gallen | Orlando | 12 |
| Tyler Anderson | South Iowa | 11 |
| Justus Sheffield | South Iowa | 11 |