| Player | Team | IP |
|---|---|---|
| German Marquez | Malibu | 243 |
| Lance Lynn | Riverside | 229.2 |
| Gerrit Cole | Guildford | 224.2 |
| Brandon Woodruff | Malibu | 221 |
| Aaron Nola | Sterling | 218.2 |
| Antonio Senzatela | Jacksonville | 216.1 |
| Dinelson Lamet | Sterling | 211 |
| Zack Greinke | Jacksonville | 208.1 |
| Shane Bieber | Jacksonville | 206 |
| Marco Gonzales | Malibu | 204.1 |
| Jacob deGrom | Sterling | 202.2 |
| Luis Castillo | Havana | 200.2 |
| Trevor Bauer | Havana | 198 |
| Hyun Jin Ryu | Havana | 195.2 |
| Carlos Carrasco | Riverside | 194 |
| Andrew Heaney | Syracuse | 192 |
| Jose Berrios | Riverside | 182.1 |
| Zach Davies | Albuquerque | 180.2 |
| Framber Valdez | Albuquerque | 176.2 |
| Corbin Burnes | Jacksonville | 175 |