| Player | Team | R |
|---|---|---|
| Patrick Corbin | Orlando | 159 |
| Kris Bubic | Orlando | 144 |
| Jose Berrios | Riverside | 136 |
| Dylan Cease | Havana | 124 |
| German Marquez | Malibu | 122 |
| Asher Wojciechowski | Chicago | 121 |
| Antonio Senzatela | Jacksonville | 120 |
| Brandon Woodruff | Malibu | 119 |
| Gerrit Cole | Guildford | 110 |
| Marco Gonzales | Malibu | 109 |
| Jake Arrieta | Albuquerque | 106 |
| Framber Valdez | Albuquerque | 104 |
| Nathan Eovaldi | Syracuse | 104 |
| Andrew Heaney | Syracuse | 103 |
| Lance Lynn | Riverside | 102 |
| Ryan Castellani | Chicago | 101 |
| Chi Chi Gonzalez | Jacksonville | 98 |
| Nick Margevicius | Chicago | 97 |
| Tyler Anderson | Orlando | 97 |
| Blake Snell | Guildford | 97 |