| Player | Team | SHO |
|---|---|---|
| Shane Bieber | Jacksonville | 3 |
| Hyun Jin Ryu | Havana | 3 |
| Tanner Houck | Guildford | 2 |
| Gerrit Cole | Guildford | 2 |
| Trevor Bauer | Havana | 2 |
| Adam Wainwright | Albuquerque | 2 |
| Sonny Gray | Malibu | 2 |
| German Marquez | Malibu | 1 |
| Andrew Heaney | Syracuse | 1 |
| Dustin May | Guildford | 1 |
| Jon Lester | Guildford | 1 |
| Lance McCullers | Guildford | 1 |
| Carlos Carrasco | Riverside | 1 |
| Corbin Burnes | Jacksonville | 1 |
| Zack Greinke | Jacksonville | 1 |
| Brad Wieck | Sterling | 1 |