| Player | Team | GS |
|---|---|---|
| Shane Bieber | Kankakee | 33 |
| Jordan Lyles | Kankakee | 31 |
| Jose Berrios | Ohio | 30 |
| Zac Gallen | Orlando | 30 |
| James Paxton | Ohio | 29 |
| Justus Sheffield | South Iowa | 29 |
| Dallas Keuchel | South Iowa | 28 |
| Zack Greinke | Albuquerque | 28 |
| Griffin Canning | Orlando | 28 |
| Trevor Bauer | Ohio | 28 |
| Kevin Gausman | Kankakee | 27 |
| Tyler Anderson | South Iowa | 27 |
| Blake Snell | Orlando | 25 |
| Jake Arrieta | Albuquerque | 25 |
| Zach Plesac | South Iowa | 24 |
| Brett Anderson | Orlando | 24 |
| Ryan Yarbrough | Kankakee | 24 |
| Dylan Cease | Ohio | 23 |
| Randy Dobnak | Kankakee | 23 |
| Jorge Lopez | Orlando | 19 |