| Player | Team | IP |
|---|---|---|
| Shane Bieber | Kankakee | 241.1 |
| Lance Lynn | Pea Ridge | 239 |
| Yu Darvish | Boise | 231.2 |
| Brandon Woodruff | Portland | 226.1 |
| Aaron Nola | Portland | 221.1 |
| Zac Gallen | Orlando | 221.1 |
| Luis Castillo | Dakota | 212.2 |
| Trevor Bauer | Ohio | 210 |
| Antonio Senzatela | Pea Ridge | 204.2 |
| Dallas Keuchel | South Iowa | 197.2 |
| Andrew Heaney | Boise | 196 |
| Jose Berrios | Ohio | 192.1 |
| Zack Greinke | Albuquerque | 188.2 |
| Tyler Anderson | South Iowa | 186.1 |
| Zach Eflin | Herefordshire | 180 |
| Hyun Jin Ryu | Pea Ridge | 178.2 |
| Justus Sheffield | South Iowa | 175.2 |
| Griffin Canning | Orlando | 174 |
| Kevin Gausman | Kankakee | 170 |
| Zach Plesac | South Iowa | 169 |