| Player | Team | SO |
|---|---|---|
| Shane Bieber | Kankakee | 405 |
| Yu Darvish | Boise | 324 |
| Trevor Bauer | Ohio | 322 |
| Aaron Nola | Portland | 312 |
| Luis Castillo | Dakota | 306 |
| Brandon Woodruff | Portland | 304 |
| Zac Gallen | Orlando | 290 |
| Kevin Gausman | Kankakee | 251 |
| Tyler Glasnow | Dakota | 239 |
| Zach Eflin | Herefordshire | 236 |
| Blake Snell | Orlando | 229 |
| Lance Lynn | Pea Ridge | 224 |
| Andrew Heaney | Boise | 214 |
| Jose Berrios | Ohio | 210 |
| Tyler Mahle | Dakota | 206 |
| Trevor Rogers | Herefordshire | 199 |
| Zack Greinke | Albuquerque | 199 |
| James Paxton | Ohio | 194 |
| Hyun Jin Ryu | Pea Ridge | 189 |
| Griffin Canning | Orlando | 185 |