| Player | Team | GS |
|---|---|---|
| Lance Lynn | Pea Ridge | 35 |
| Luis Castillo | Dakota | 35 |
| Aaron Nola | Portland | 33 |
| Brandon Woodruff | Portland | 33 |
| Shane Bieber | Kankakee | 33 |
| Jordan Lyles | Kankakee | 31 |
| Antonio Senzatela | Pea Ridge | 31 |
| Yu Darvish | Boise | 30 |
| Jose Berrios | Ohio | 30 |
| Zac Gallen | Orlando | 30 |
| Mike Fiers | Dakota | 29 |
| James Paxton | Ohio | 29 |
| Justus Sheffield | South Iowa | 29 |
| Dallas Keuchel | South Iowa | 28 |
| Zack Greinke | Albuquerque | 28 |
| Griffin Canning | Orlando | 28 |
| Trevor Bauer | Ohio | 28 |
| Hyun Jin Ryu | Pea Ridge | 28 |
| Zach Eflin | Herefordshire | 28 |
| Jake Odorizzi | Herefordshire | 27 |