| Player | Team | L |
|---|---|---|
| Jordan Lyles | Kankakee | 20 |
| Jake Odorizzi | Herefordshire | 15 |
| Nathan Eovaldi | Portland | 15 |
| James Paxton | Ohio | 14 |
| Tanner Roark | Herefordshire | 14 |
| Trevor Rogers | Herefordshire | 13 |
| Zac Gallen | Orlando | 13 |
| Blake Snell | Orlando | 13 |
| Dallas Keuchel | South Iowa | 13 |
| Wade Leblanc | South Iowa | 12 |
| Tyler Anderson | South Iowa | 12 |
| Patrick Corbin | Portland | 12 |
| Luis Castillo | Dakota | 12 |
| Lance Lynn | Pea Ridge | 11 |
| Hyun Jin Ryu | Pea Ridge | 11 |
| Thomas Hatch | Dakota | 11 |
| Mike Fiers | Dakota | 11 |
| Justin Dunn | Boise | 11 |
| Griffin Canning | Orlando | 11 |
| Kris Bubic | Orlando | 10 |