| Player | Team | 2B |
|---|---|---|
| Justus Sheffield | South Iowa | 53 |
| Brett Anderson | Orlando | 53 |
| Yu Darvish | Boise | 49 |
| Patrick Corbin | Portland | 49 |
| Antonio Senzatela | Pea Ridge | 48 |
| Griffin Canning | Orlando | 45 |
| Tyler Anderson | South Iowa | 44 |
| Hyun Jin Ryu | Pea Ridge | 44 |
| Zack Greinke | Albuquerque | 42 |
| Luis Castillo | Dakota | 41 |
| Zac Gallen | Orlando | 39 |
| Logan Webb | Albuquerque | 38 |
| Zach Eflin | Herefordshire | 38 |
| Lance Lynn | Pea Ridge | 37 |
| Nathan Eovaldi | Portland | 37 |
| Jose Berrios | Ohio | 37 |
| Mike Fiers | Dakota | 37 |
| James Paxton | Ohio | 36 |
| Masahiro Tanaka | Boise | 34 |
| Jake Arrieta | Albuquerque | 34 |