| Player | Team | IP |
|---|---|---|
| Kyle Hendricks | Arizona | 235.1 |
| Gerrit Cole | Tacoma | 228.2 |
| Lucas Giolito | Chicago | 217 |
| Jacob deGrom | Arizona | 212.2 |
| Marco Gonzales | Foscoe | 211.2 |
| German Marquez | Brooklyn | 211 |
| Framber Valdez | Foscoe | 209.2 |
| Dinelson Lamet | Fraser | 207.1 |
| Dylan Bundy | Kansas City | 203 |
| Aaron Civale | Tacoma | 200.1 |
| Adam Wainwright | Montana | 200.1 |
| Brady Singer | Kansas City | 200 |
| Zach Davies | Kansas City | 200 |
| Zack Wheeler | Fraser | 198.2 |
| Carlos Carrasco | Foscoe | 196.1 |
| Kenta Maeda | Fraser | 196 |
| Martin Perez | Chicago | 192.1 |
| Jon Lester | Southland | 187 |
| Max Scherzer | Foscoe | 185.2 |
| Luke Weaver | Chicago | 180.1 |