| Player | Team | R |
|---|---|---|
| Kyle Freeland | Chicago | 170 |
| Trevor Williams | Chicago | 161 |
| Martin Perez | Chicago | 158 |
| Kyle Gibson | Montana | 150 |
| Anthony DeSclafani | Tacoma | 132 |
| Gerrit Cole | Tacoma | 132 |
| Aaron Civale | Tacoma | 128 |
| Kyle Hendricks | Arizona | 126 |
| Dustin May | Arizona | 117 |
| Luke Weaver | Chicago | 117 |
| Zack Wheeler | Fraser | 117 |
| Jon Lester | Southland | 114 |
| Max Scherzer | Foscoe | 110 |
| German Marquez | Brooklyn | 109 |
| Framber Valdez | Foscoe | 107 |
| Michael Wacha | Tacoma | 103 |
| Brady Singer | Kansas City | 103 |
| Ross Stripling | Montana | 97 |
| Austin Voth | Montana | 96 |
| Jesus Luzardo | Fraser | 96 |