| Player | Team | SO |
|---|---|---|
| Jacob deGrom | Arizona | 370 |
| Lucas Giolito | Chicago | 335 |
| Gerrit Cole | Tacoma | 335 |
| Dinelson Lamet | Fraser | 293 |
| Carlos Carrasco | Foscoe | 271 |
| Corbin Burnes | Brooklyn | 255 |
| Framber Valdez | Foscoe | 254 |
| Max Scherzer | Foscoe | 250 |
| Clayton Kershaw | Brooklyn | 224 |
| Kenta Maeda | Fraser | 221 |
| Aaron Civale | Tacoma | 220 |
| Sonny Gray | Tacoma | 219 |
| Marco Gonzales | Foscoe | 218 |
| Dylan Bundy | Kansas City | 217 |
| Luke Weaver | Chicago | 212 |
| Pablo Lopez | Colorado | 208 |
| Kyle Hendricks | Arizona | 206 |
| Zach Davies | Kansas City | 198 |
| German Marquez | Brooklyn | 197 |
| Brady Singer | Kansas City | 190 |