| Player | Team | L |
|---|---|---|
| Trevor Williams | Chicago | 20 |
| Kyle Freeland | Chicago | 19 |
| Martin Perez | Chicago | 17 |
| Aaron Civale | Tacoma | 17 |
| Kyle Gibson | Montana | 17 |
| Marco Gonzales | Foscoe | 16 |
| Kyle Hendricks | Arizona | 16 |
| Anthony DeSclafani | Tacoma | 15 |
| Luke Weaver | Chicago | 15 |
| Dustin May | Arizona | 14 |
| Michael Wacha | Tacoma | 14 |
| Mike Minor | Southland | 13 |
| Lucas Giolito | Chicago | 13 |
| Brady Singer | Kansas City | 13 |
| Jaime Barria | Kansas City | 12 |
| Dylan Bundy | Kansas City | 12 |
| Gerrit Cole | Tacoma | 12 |
| Chad Kuhl | Southland | 12 |
| Jon Lester | Southland | 11 |
| Max Scherzer | Foscoe | 11 |