| Player | Team | 2B |
|---|---|---|
| Kyle Freeland | Chicago | 63 |
| German Marquez | Brooklyn | 60 |
| Kyle Hendricks | Arizona | 54 |
| Aaron Civale | Tacoma | 52 |
| Martin Perez | Chicago | 49 |
| Michael Wacha | Tacoma | 45 |
| Luke Weaver | Chicago | 45 |
| Zack Wheeler | Fraser | 44 |
| Rick Porcello | Chicago | 42 |
| Lucas Giolito | Chicago | 41 |
| Jesus Luzardo | Fraser | 41 |
| Kyle Gibson | Montana | 40 |
| Dylan Bundy | Kansas City | 39 |
| Trevor Williams | Chicago | 39 |
| Max Scherzer | Foscoe | 39 |
| Carlos Carrasco | Foscoe | 37 |
| Garrett Richards | Kansas City | 37 |
| Brady Singer | Kansas City | 37 |
| Framber Valdez | Foscoe | 36 |
| Adam Wainwright | Montana | 36 |