| Player | Team | IP |
|---|---|---|
| Shane Bieber | Kankakee | 241.1 |
| Zac Gallen | Orlando | 221.1 |
| Trevor Bauer | Ohio | 210 |
| Dallas Keuchel | South Iowa | 197.2 |
| Jose Berrios | Ohio | 192.1 |
| Zack Greinke | Albuquerque | 188.2 |
| Tyler Anderson | South Iowa | 186.1 |
| Justus Sheffield | South Iowa | 175.2 |
| Griffin Canning | Orlando | 174 |
| Kevin Gausman | Kankakee | 170 |
| Zach Plesac | South Iowa | 169 |
| Blake Snell | Orlando | 158 |
| Brett Anderson | Orlando | 147.2 |
| Dylan Cease | Ohio | 147.1 |
| James Paxton | Ohio | 146.2 |
| Logan Webb | Albuquerque | 143 |
| Jake Arrieta | Albuquerque | 136.1 |
| Ryan Yarbrough | Kankakee | 130 |
| Jordan Lyles | Kankakee | 127.2 |
| Randy Dobnak | Kankakee | 126 |