| Player | Team | R |
|---|---|---|
| Jordan Lyles | Kankakee | 156 |
| Griffin Canning | Orlando | 127 |
| Zac Gallen | Orlando | 121 |
| Blake Snell | Orlando | 120 |
| James Paxton | Ohio | 120 |
| Brett Anderson | Orlando | 118 |
| Justus Sheffield | South Iowa | 115 |
| Logan Webb | Albuquerque | 115 |
| Jake Arrieta | Albuquerque | 112 |
| Tyler Anderson | South Iowa | 108 |
| Jose Berrios | Ohio | 102 |
| Chi Chi Gonzalez | South Iowa | 101 |
| Dylan Cease | Ohio | 99 |
| Wade Leblanc | South Iowa | 95 |
| Tommy Milone | Ohio | 94 |
| Matt Shoemaker | Albuquerque | 91 |
| Anibal Sanchez | Kankakee | 90 |
| Zack Greinke | Albuquerque | 88 |
| Dallas Keuchel | South Iowa | 83 |
| Kris Bubic | Orlando | 78 |