| Player | Team | SO |
|---|---|---|
| Shane Bieber | Kankakee | 405 |
| Trevor Bauer | Ohio | 322 |
| Zac Gallen | Orlando | 290 |
| Kevin Gausman | Kankakee | 251 |
| Blake Snell | Orlando | 229 |
| Jose Berrios | Ohio | 210 |
| Zack Greinke | Albuquerque | 199 |
| James Paxton | Ohio | 194 |
| Griffin Canning | Orlando | 185 |
| Zach Plesac | South Iowa | 175 |
| Justus Sheffield | South Iowa | 171 |
| Cristian Javier | Orlando | 142 |
| Dylan Cease | Ohio | 133 |
| Triston McKenzie | Ohio | 128 |
| Edwin Diaz | South Iowa | 124 |
| Josh Tomlin | Albuquerque | 121 |
| Nate Pearson | Ohio | 121 |
| Brett Anderson | Orlando | 121 |
| Logan Webb | Albuquerque | 118 |
| James Karinchak | Albuquerque | 116 |