| Player | Team | L |
|---|---|---|
| Jordan Lyles | Kankakee | 20 |
| James Paxton | Ohio | 14 |
| Zac Gallen | Orlando | 13 |
| Blake Snell | Orlando | 13 |
| Dallas Keuchel | South Iowa | 13 |
| Wade Leblanc | South Iowa | 12 |
| Tyler Anderson | South Iowa | 12 |
| Griffin Canning | Orlando | 11 |
| Kris Bubic | Orlando | 10 |
| Brett Anderson | Orlando | 10 |
| Dylan Cease | Ohio | 10 |
| Chi Chi Gonzalez | South Iowa | 10 |
| Justus Sheffield | South Iowa | 10 |
| Jake Arrieta | Albuquerque | 10 |
| Jorge Lopez | Orlando | 9 |
| Casey Mize | Kankakee | 8 |
| Shane Bieber | Kankakee | 8 |
| Zach Plesac | South Iowa | 8 |
| Matt Shoemaker | Albuquerque | 7 |
| Ryan Yarbrough | Kankakee | 7 |