| Player | Team | 2B |
|---|---|---|
| Justus Sheffield | South Iowa | 53 |
| Brett Anderson | Orlando | 53 |
| Griffin Canning | Orlando | 45 |
| Tyler Anderson | South Iowa | 44 |
| Zack Greinke | Albuquerque | 42 |
| Zac Gallen | Orlando | 39 |
| Logan Webb | Albuquerque | 38 |
| Jose Berrios | Ohio | 37 |
| James Paxton | Ohio | 36 |
| Jake Arrieta | Albuquerque | 34 |
| Randy Dobnak | Kankakee | 33 |
| Tommy Milone | Ohio | 31 |
| Blake Snell | Orlando | 31 |
| Dallas Keuchel | South Iowa | 31 |
| Jorge Lopez | Orlando | 29 |
| Zach Plesac | South Iowa | 28 |
| Jordan Lyles | Kankakee | 28 |
| Shane Bieber | Kankakee | 28 |
| Chi Chi Gonzalez | South Iowa | 26 |
| Kevin Gausman | Kankakee | 25 |