| Player | Team | HR |
|---|---|---|
| Gerrit Cole | Tacoma | 68 |
| Blake Snell | Orlando | 57 |
| Jake Odorizzi | Herefordshire | 55 |
| Jordan Lyles | Kankakee | 50 |
| Lance Lynn | Pea Ridge | 49 |
| Jon Lester | Southland | 45 |
| Dustin May | Arizona | 44 |
| Trevor Williams | Chicago | 44 |
| Wade Leblanc | South Iowa | 44 |
| Matt Shoemaker | Albuquerque | 44 |
| Kyle Gibson | Montana | 44 |
| Andrew Heaney | Boise | 43 |
| Trevor Rogers | Herefordshire | 43 |
| Martin Perez | Chicago | 42 |
| Anthony DeSclafani | Tacoma | 42 |
| Brandon Woodruff | Portland | 42 |
| Austin Voth | Montana | 42 |
| Justin Dunn | Boise | 41 |
| Dylan Cease | Ohio | 41 |
| Asher Wojciechowski | Dakota | 40 |