| Player | Team | IP |
|---|---|---|
| Kyle Hendricks | Kansas City | 231.1 |
| Yu Darvish | Kansas City | 225.2 |
| Zac Gallen | California | 223 |
| Zack Wheeler | Las Vegas | 217 |
| Rick Porcello | New York | 216.1 |
| Dylan Bundy | St. Louis | 208 |
| Kyle Freeland | Gallup | 207 |
| Max Scherzer | California | 206.2 |
| Frankie Montas | Gallup | 203.1 |
| Brady Singer | New Jersey | 198.1 |
| Kenta Maeda | Kansas City | 198.1 |
| Dallas Keuchel | California | 193 |
| Lucas Giolito | Las Vegas | 191 |
| Logan Webb | Gallup | 178.2 |
| Chris Bassitt | Tampa | 177.2 |
| Jesus Luzardo | Las Vegas | 175 |
| Griffin Canning | New Jersey | 174.2 |
| Spencer Turnbull | California | 174.1 |
| Kevin Gausman | Tampa | 173.2 |
| Martin Perez | Kansas City | 173.2 |