| Player | Team | SO |
|---|---|---|
| Yu Darvish | Kansas City | 335 |
| Max Scherzer | California | 303 |
| Zac Gallen | California | 298 |
| Lucas Giolito | Las Vegas | 290 |
| Kenta Maeda | Kansas City | 251 |
| Trevor Rogers | New York | 248 |
| Dylan Bundy | St. Louis | 247 |
| Kevin Gausman | Tampa | 247 |
| Frankie Montas | Gallup | 243 |
| Zack Wheeler | Las Vegas | 226 |
| Kyle Hendricks | Kansas City | 221 |
| Rick Porcello | New York | 220 |
| Pablo Lopez | New York | 211 |
| Tyler Mahle | Boston | 209 |
| Chris Paddack | Gallup | 184 |
| Logan Webb | Gallup | 180 |
| Griffin Canning | New Jersey | 180 |
| Brady Singer | New Jersey | 178 |
| Jesus Luzardo | Las Vegas | 168 |
| Aaron Civale | Kansas City | 167 |