| Player | Team | 2B |
|---|---|---|
| Kyle Freeland | Gallup | 71 |
| Rick Porcello | New York | 61 |
| Anibal Sanchez | New York | 51 |
| Jesus Luzardo | Las Vegas | 50 |
| Mike Fiers | New Jersey | 49 |
| Ryan Yarbrough | Tampa | 47 |
| Max Scherzer | California | 45 |
| Zack Wheeler | Las Vegas | 44 |
| Jordan Lyles | St. Louis | 43 |
| Zack Godley | New York | 43 |
| Yu Darvish | Kansas City | 42 |
| Frankie Montas | Gallup | 42 |
| Dylan Bundy | St. Louis | 41 |
| Chris Bassitt | Tampa | 41 |
| Aaron Civale | Kansas City | 41 |
| Kyle Hendricks | Kansas City | 41 |
| Trevor Rogers | New York | 40 |
| Chris Paddack | Gallup | 40 |
| Dallas Keuchel | California | 40 |
| Spencer Turnbull | California | 38 |