| Player | Team | SO |
|---|---|---|
| Shane Bieber | Jacksonville | 338 |
| Jacob deGrom | Sterling | 336 |
| Aaron Nola | Sterling | 323 |
| Brandon Woodruff | Malibu | 314 |
| Luis Castillo | Havana | 298 |
| Trevor Bauer | Havana | 292 |
| Dinelson Lamet | Sterling | 286 |
| Gerrit Cole | Guildford | 285 |
| Corbin Burnes | Jacksonville | 279 |
| Carlos Carrasco | Riverside | 265 |
| Sonny Gray | Malibu | 238 |
| Tyler Glasnow | Havana | 232 |
| Lance Lynn | Riverside | 224 |
| Blake Snell | Guildford | 222 |
| Zack Greinke | Jacksonville | 213 |
| German Marquez | Malibu | 211 |
| Framber Valdez | Albuquerque | 202 |
| Hyun Jin Ryu | Havana | 200 |
| Jose Berrios | Riverside | 196 |
| Marco Gonzales | Malibu | 195 |