| Player | Team | HB |
|---|---|---|
| Chi Chi Gonzalez | Jacksonville | 30 |
| Ryan Castellani | Chicago | 22 |
| Brett Anderson | Chicago | 21 |
| Genesis Cabrera | Syracuse | 20 |
| Lance McCullers | Guildford | 19 |
| Darren O'Day | Guildford | 19 |
| Nathan Eovaldi | Syracuse | 17 |
| Adrian Houser | Orlando | 17 |
| Jose Berrios | Riverside | 17 |
| Lance Lynn | Riverside | 16 |
| Dinelson Lamet | Sterling | 16 |
| Brandon Woodruff | Malibu | 16 |
| Yency Almonte | Chicago | 15 |
| Dylan Cease | Havana | 15 |
| Trevor Bauer | Havana | 14 |
| Framber Valdez | Albuquerque | 14 |
| Antonio Senzatela | Jacksonville | 14 |
| Corbin Burnes | Jacksonville | 14 |
| Carlos Rodon | Jacksonville | 13 |
| Sixto Sanchez | Syracuse | 13 |