| Player | Team | 2B |
|---|---|---|
| Patrick Corbin | Orlando | 55 |
| German Marquez | Malibu | 53 |
| Kris Bubic | Orlando | 47 |
| Nick Margevicius | Chicago | 45 |
| Framber Valdez | Albuquerque | 44 |
| Brett Anderson | Chicago | 44 |
| Justus Sheffield | Syracuse | 44 |
| Luis Castillo | Havana | 44 |
| Jon Lester | Guildford | 43 |
| Tyler Anderson | Orlando | 42 |
| Jose Berrios | Riverside | 42 |
| Brandon Woodruff | Malibu | 41 |
| Marco Gonzales | Malibu | 39 |
| Aaron Nola | Sterling | 39 |
| Jake Arrieta | Albuquerque | 38 |
| Chi Chi Gonzalez | Jacksonville | 37 |
| Zack Greinke | Jacksonville | 37 |
| Yusei Kikuchi | Guildford | 36 |
| Antonio Senzatela | Jacksonville | 35 |
| Jonathan Brubaker | Albuquerque | 35 |