| Player | Team | IP |
|---|---|---|
| Kyle Hendricks | Kansas City | 231.1 |
| Yu Darvish | Kansas City | 225.2 |
| Rick Porcello | New York | 216.1 |
| Kyle Freeland | Gallup | 207 |
| Frankie Montas | Gallup | 203.1 |
| Kenta Maeda | Kansas City | 198.1 |
| Logan Webb | Gallup | 178.2 |
| Martin Perez | Kansas City | 173.2 |
| Pablo Lopez | New York | 173.1 |
| Anibal Sanchez | New York | 169.1 |
| Trevor Rogers | New York | 167 |
| Chris Paddack | Gallup | 166.2 |
| Aaron Civale | Kansas City | 165.1 |
| Taijuan Walker | Manhattan | 160 |
| Garrett Richards | Boston | 154.2 |
| Zack Godley | New York | 154.1 |
| J.A. Happ | Manhattan | 153.2 |
| Matthew Boyd | Gallup | 153.1 |
| Alex Cobb | Boston | 144 |
| Randy Dobnak | Boston | 142.2 |