| Player | Team | SO |
|---|---|---|
| Yu Darvish | Kansas City | 335 |
| Kenta Maeda | Kansas City | 251 |
| Trevor Rogers | New York | 248 |
| Frankie Montas | Gallup | 243 |
| Kyle Hendricks | Kansas City | 221 |
| Rick Porcello | New York | 220 |
| Pablo Lopez | New York | 211 |
| Tyler Mahle | Boston | 209 |
| Chris Paddack | Gallup | 184 |
| Logan Webb | Gallup | 180 |
| Aaron Civale | Kansas City | 167 |
| Taijuan Walker | Manhattan | 162 |
| Zack Godley | New York | 160 |
| Kyle Freeland | Gallup | 155 |
| Matthew Boyd | Gallup | 150 |
| J.A. Happ | Manhattan | 149 |
| Garrett Richards | Boston | 144 |
| Michael Wacha | Boston | 142 |
| Anibal Sanchez | New York | 139 |
| Steven Brault | Manhattan | 135 |