| Player | Team | 2B |
|---|---|---|
| Kyle Freeland | Gallup | 71 |
| Rick Porcello | New York | 61 |
| Anibal Sanchez | New York | 51 |
| Zack Godley | New York | 43 |
| Yu Darvish | Kansas City | 42 |
| Frankie Montas | Gallup | 42 |
| Aaron Civale | Kansas City | 41 |
| Kyle Hendricks | Kansas City | 41 |
| Trevor Rogers | New York | 40 |
| Chris Paddack | Gallup | 40 |
| Logan Webb | Gallup | 38 |
| Randy Dobnak | Boston | 33 |
| Garrett Richards | Boston | 32 |
| Matthew Boyd | Gallup | 31 |
| Taijuan Walker | Manhattan | 30 |
| Alex Cobb | Boston | 30 |
| Pablo Lopez | New York | 29 |
| Martin Perez | Kansas City | 25 |
| Michael Wacha | Boston | 24 |
| Jordan Montgomery | Manhattan | 24 |