| Player | Team | HR |
|---|---|---|
| Gerrit Cole | Guildford | 56 |
| Masahiro Tanaka | Las Vegas | 55 |
| Matthew Boyd | Gallup | 52 |
| Ryan Castellani | Chicago | 48 |
| Jordan Lyles | St. Louis | 47 |
| Lance Lynn | Riverside | 47 |
| Asher Wojciechowski | Chicago | 45 |
| Jonathan Stiever | St. Louis | 42 |
| Chris Paddack | Gallup | 42 |
| Anibal Sanchez | New York | 42 |
| Zack Godley | New York | 41 |
| Blake Snell | Guildford | 41 |
| John Means | New Jersey | 40 |
| Andrew Heaney | Syracuse | 39 |
| J.A. Happ | Manhattan | 39 |
| Dylan Cease | Havana | 39 |
| Brandon Woodruff | Malibu | 38 |
| Patrick Corbin | Orlando | 37 |
| Reynaldo Lopez | Syracuse | 37 |
| Trevor Rogers | New York | 37 |