| Player | Team | L |
|---|---|---|
| Patrick Corbin | Orlando | 21 |
| Kyle Freeland | Gallup | 20 |
| Anibal Sanchez | New York | 19 |
| Zack Godley | New York | 19 |
| Jordan Lyles | St. Louis | 19 |
| Rick Porcello | New York | 17 |
| Frankie Montas | Gallup | 16 |
| Kris Bubic | Orlando | 16 |
| Tyler Anderson | Orlando | 15 |
| Jake Arrieta | Albuquerque | 15 |
| Trevor Rogers | New York | 15 |
| Chris Paddack | Gallup | 15 |
| Nick Margevicius | Chicago | 14 |
| Framber Valdez | Albuquerque | 14 |
| Max Scherzer | California | 13 |
| Brandon Woodruff | Malibu | 13 |
| Antonio Senzatela | Jacksonville | 13 |
| Logan Webb | Gallup | 13 |
| Matthew Boyd | Gallup | 13 |
| J.A. Happ | Manhattan | 13 |