| Player | Team | HR |
|---|---|---|
| Frankie Montas | Wisc. Rapids | 56 |
| Anibal Sanchez | Wisc. Rapids | 55 |
| John Means | El Paso | 54 |
| Braxton Garrett | Oak Lawn | 52 |
| Dylan Cease | Dayton | 51 |
| Madison Bumgarner | El Paso | 50 |
| Alec Mills | Monet | 47 |
| Blake Snell | Dayton | 40 |
| Aaron Civale | El Paso | 38 |
| Lance Lynn | Brooklyn | 38 |
| Zack Greinke | Wisc. Rapids | 38 |
| Trevor Bauer | Peculiar | 38 |
| Mike Fiers | Chicago | 37 |
| Nathan Eovaldi | El Paso | 36 |
| Zach Eflin | Chicago | 35 |
| Brandon Woodruff | Dayton | 35 |
| Reynaldo Lopez | Wisc. Rapids | 34 |
| Alex Cobb | Milwaukee | 33 |
| Kenta Maeda | Monet | 33 |
| Kyle Freeland | Monet | 33 |