| Player | Team | IP |
|---|---|---|
| Shane Bieber | Peculiar | 231.2 |
| Lance Lynn | Brooklyn | 228.2 |
| Brandon Woodruff | Dayton | 225 |
| Zack Wheeler | Brooklyn | 214.2 |
| Antonio Senzatela | El Paso | 210.1 |
| Trevor Bauer | Peculiar | 210.1 |
| Framber Valdez | Brooklyn | 205 |
| Kenta Maeda | Monet | 203.1 |
| Kyle Freeland | Monet | 203 |
| Carlos Carrasco | Peculiar | 202.1 |
| Zack Greinke | Wisc. Rapids | 195.1 |
| Alec Mills | Monet | 192.2 |
| Aaron Civale | El Paso | 189.1 |
| Frankie Montas | Wisc. Rapids | 186.1 |
| Chris Bassitt | Chicago | 186.1 |
| Hyun Jin Ryu | Wisc. Rapids | 184.1 |
| Martin Perez | Chicago | 182.2 |
| Anibal Sanchez | Wisc. Rapids | 182.1 |
| Dylan Cease | Dayton | 178.1 |
| Tyler Anderson | Monet | 177.2 |