| Player | Team | SO |
|---|---|---|
| Shane Bieber | Peculiar | 369 |
| Trevor Bauer | Peculiar | 343 |
| Brandon Woodruff | Dayton | 305 |
| Carlos Carrasco | Peculiar | 280 |
| Lucas Giolito | Elko | 264 |
| Kenta Maeda | Monet | 264 |
| Sonny Gray | Peculiar | 259 |
| Corbin Burnes | Elko | 255 |
| Zack Greinke | Wisc. Rapids | 254 |
| Zach Eflin | Chicago | 253 |
| Framber Valdez | Brooklyn | 238 |
| Frankie Montas | Wisc. Rapids | 233 |
| Tyler Glasnow | Elko | 221 |
| Lance Lynn | Brooklyn | 218 |
| Luis Castillo | Peculiar | 215 |
| Zack Wheeler | Brooklyn | 205 |
| Hyun Jin Ryu | Wisc. Rapids | 198 |
| Dylan Bundy | Milwaukee | 193 |
| Blake Snell | Dayton | 193 |
| Lance McCullers | Oak Lawn | 190 |