| Player | Team | GS |
|---|---|---|
| Zack Wheeler | Brooklyn | 37 |
| Lance Lynn | Brooklyn | 35 |
| Antonio Senzatela | El Paso | 33 |
| Brandon Woodruff | Dayton | 33 |
| Shane Bieber | Peculiar | 33 |
| Trevor Bauer | Peculiar | 32 |
| Framber Valdez | Brooklyn | 32 |
| Kyle Freeland | Monet | 31 |
| Dylan Cease | Dayton | 31 |
| Carlos Carrasco | Peculiar | 31 |
| Frankie Montas | Wisc. Rapids | 31 |
| Zack Greinke | Wisc. Rapids | 31 |
| Chris Bassitt | Chicago | 31 |
| Martin Perez | Chicago | 31 |
| Mike Fiers | Chicago | 30 |
| Zach Eflin | Chicago | 30 |
| Anibal Sanchez | Wisc. Rapids | 30 |
| Braxton Garrett | Oak Lawn | 30 |
| Aaron Civale | El Paso | 30 |
| Alec Mills | Monet | 28 |