| Player | Team | L |
|---|---|---|
| Kris Bubic | Monet | 18 |
| Braxton Garrett | Oak Lawn | 18 |
| Frankie Montas | Wisc. Rapids | 17 |
| Anibal Sanchez | Wisc. Rapids | 16 |
| Zack Wheeler | Brooklyn | 16 |
| Aaron Civale | El Paso | 15 |
| Zach Eflin | Chicago | 15 |
| Ryan Yarbrough | El Paso | 14 |
| Kyle Freeland | Monet | 14 |
| John Means | El Paso | 13 |
| Antonio Senzatela | El Paso | 13 |
| Mike Fiers | Chicago | 13 |
| Martin Perez | Chicago | 13 |
| Zack Greinke | Wisc. Rapids | 13 |
| Hyun Jin Ryu | Wisc. Rapids | 12 |
| Brett Anderson | Milwaukee | 12 |
| Dylan Cease | Dayton | 12 |
| Blake Snell | Dayton | 11 |
| Brandon Woodruff | Dayton | 11 |
| Patrick Corbin | Brooklyn | 11 |