| Player | Team | H |
|---|---|---|
| Anibal Sanchez | Wisc. Rapids | 262 |
| Kyle Freeland | Monet | 254 |
| Zack Greinke | Wisc. Rapids | 238 |
| Zack Wheeler | Brooklyn | 237 |
| Aaron Civale | El Paso | 237 |
| Frankie Montas | Wisc. Rapids | 232 |
| Antonio Senzatela | El Paso | 226 |
| Patrick Corbin | Brooklyn | 221 |
| Lance Lynn | Brooklyn | 205 |
| Ryan Yarbrough | El Paso | 196 |
| Adrian Houser | Chicago | 194 |
| Nathan Eovaldi | El Paso | 193 |
| Framber Valdez | Brooklyn | 192 |
| Zach Eflin | Chicago | 191 |
| Hyun Jin Ryu | Wisc. Rapids | 189 |
| Mike Fiers | Chicago | 188 |
| Randy Dobnak | Oak Lawn | 188 |
| Brandon Woodruff | Dayton | 188 |
| Martin Perez | Chicago | 185 |
| Chris Bassitt | Chicago | 179 |