| Player | Team | IP |
|---|---|---|
| German Marquez | Clinton | 244 |
| Kyle Hendricks | Connecticut | 241 |
| Gerrit Cole | Burlington | 220.1 |
| Marco Gonzales | Orlando | 219 |
| Cole Hamels | Clinton | 217.2 |
| Aaron Nola | Burlington | 215.2 |
| Dinelson Lamet | Clinton | 208.1 |
| Rick Porcello | Phoenix | 205 |
| Zach Davies | Clinton | 204 |
| Brady Singer | Orlando | 201 |
| Yu Darvish | Torrance Beach | 198 |
| Seth Lugo | Amarillo | 196.2 |
| Zac Gallen | Torrance Beach | 193.2 |
| Kyle Gibson | Detroit | 187.2 |
| Max Scherzer | Clinton | 183.1 |
| Jacob deGrom | Huntington Beach | 180.1 |
| Logan Webb | Amarillo | 178.1 |
| Spencer Turnbull | Niagara Falls | 171.2 |
| Jesus Luzardo | Huntington Beach | 167.1 |
| Clayton Kershaw | Connecticut | 166.2 |