| Player | Team | SO |
|---|---|---|
| Jacob deGrom | Huntington Beach | 294 |
| Dinelson Lamet | Clinton | 293 |
| Aaron Nola | Burlington | 292 |
| Gerrit Cole | Burlington | 286 |
| Seth Lugo | Amarillo | 283 |
| Yu Darvish | Torrance Beach | 273 |
| Zac Gallen | Torrance Beach | 256 |
| Max Scherzer | Clinton | 242 |
| German Marquez | Clinton | 230 |
| Kyle Hendricks | Connecticut | 228 |
| Zach Davies | Clinton | 224 |
| Marco Gonzales | Orlando | 214 |
| Rick Porcello | Phoenix | 211 |
| Tyler Mahle | Niagara Falls | 195 |
| Logan Webb | Amarillo | 192 |
| Clayton Kershaw | Connecticut | 186 |
| Brady Singer | Orlando | 181 |
| Jesus Luzardo | Huntington Beach | 178 |
| Cristian Javier | Orlando | 177 |
| Joe Musgrove | Detroit | 172 |