| Player | Team | L |
|---|---|---|
| Seth Lugo | Amarillo | 21 |
| Ryan Castellani | Burlington | 18 |
| Aaron Nola | Burlington | 17 |
| Kyle Gibson | Detroit | 17 |
| Kyle Hendricks | Connecticut | 16 |
| Mike Minor | Connecticut | 15 |
| Jake Arrieta | Connecticut | 14 |
| Jesus Luzardo | Huntington Beach | 14 |
| Trevor Williams | Amarillo | 14 |
| Logan Webb | Amarillo | 13 |
| Jake Odorizzi | Amarillo | 13 |
| Austin Voth | Burlington | 13 |
| German Marquez | Clinton | 13 |
| Masahiro Tanaka | Huntington Beach | 12 |
| Yu Darvish | Torrance Beach | 11 |
| Wade Leblanc | Clinton | 11 |
| Chris Paddack | Huntington Beach | 11 |
| Carlos Martinez | Huntington Beach | 11 |
| Zack Godley | Niagara Falls | 11 |
| Asher Wojciechowski | Phoenix | 10 |