| Player | Team | H |
|---|---|---|
| German Marquez | Clinton | 283 |
| Rick Porcello | Phoenix | 258 |
| Logan Webb | Amarillo | 253 |
| Kyle Hendricks | Connecticut | 225 |
| Seth Lugo | Amarillo | 213 |
| Trevor Williams | Amarillo | 213 |
| Jake Odorizzi | Amarillo | 209 |
| Aaron Nola | Burlington | 205 |
| Austin Voth | Burlington | 202 |
| Kyle Gibson | Detroit | 195 |
| Tanner Roark | Detroit | 195 |
| Marco Gonzales | Orlando | 186 |
| Gerrit Cole | Burlington | 181 |
| Max Scherzer | Clinton | 178 |
| Yu Darvish | Torrance Beach | 175 |
| Zach Davies | Clinton | 170 |
| Zac Gallen | Torrance Beach | 169 |
| Mike Minor | Connecticut | 169 |
| Jesus Luzardo | Huntington Beach | 165 |
| Asher Wojciechowski | Phoenix | 165 |