| Player | Team | 2B |
|---|---|---|
| German Marquez | Clinton | 61 |
| Logan Webb | Amarillo | 51 |
| Rick Porcello | Phoenix | 50 |
| Garrett Richards | Torrance Beach | 40 |
| Jake Odorizzi | Amarillo | 40 |
| Kyle Hendricks | Connecticut | 39 |
| Jesus Luzardo | Huntington Beach | 38 |
| Trevor Williams | Amarillo | 37 |
| Joey Lucchesi | Detroit | 37 |
| Kyle Gibson | Detroit | 37 |
| Max Scherzer | Clinton | 37 |
| Marco Gonzales | Orlando | 37 |
| Gerrit Cole | Burlington | 35 |
| Spencer Turnbull | Niagara Falls | 35 |
| Yu Darvish | Torrance Beach | 34 |
| Cole Hamels | Clinton | 34 |
| Brady Singer | Orlando | 33 |
| Max Fried | Burlington | 33 |
| Masahiro Tanaka | Huntington Beach | 32 |
| Jake Arrieta | Connecticut | 32 |