| Player | Team | HR |
|---|---|---|
| Frankie Montas | Wisc. Rapids | 56 |
| Anibal Sanchez | Wisc. Rapids | 55 |
| John Means | El Paso | 54 |
| Madison Bumgarner | El Paso | 50 |
| Aaron Civale | El Paso | 38 |
| Zack Greinke | Wisc. Rapids | 38 |
| Trevor Bauer | Peculiar | 38 |
| Mike Fiers | Chicago | 37 |
| Nathan Eovaldi | El Paso | 36 |
| Zach Eflin | Chicago | 35 |
| Reynaldo Lopez | Wisc. Rapids | 34 |
| Alex Cobb | Milwaukee | 33 |
| Antonio Senzatela | El Paso | 31 |
| Shane Bieber | Peculiar | 30 |
| Hyun Jin Ryu | Wisc. Rapids | 28 |
| Martin Perez | Chicago | 26 |
| Carlos Carrasco | Peculiar | 25 |
| Nick Nelson | El Paso | 25 |
| Johnny Cueto | Milwaukee | 24 |
| Kyle Wright | Chicago | 24 |