| Player | Team | IP |
|---|---|---|
| Shane Bieber | Peculiar | 231.2 |
| Antonio Senzatela | El Paso | 210.1 |
| Trevor Bauer | Peculiar | 210.1 |
| Carlos Carrasco | Peculiar | 202.1 |
| Zack Greinke | Wisc. Rapids | 195.1 |
| Aaron Civale | El Paso | 189.1 |
| Frankie Montas | Wisc. Rapids | 186.1 |
| Chris Bassitt | Chicago | 186.1 |
| Hyun Jin Ryu | Wisc. Rapids | 184.1 |
| Martin Perez | Chicago | 182.2 |
| Anibal Sanchez | Wisc. Rapids | 182.1 |
| Johnny Cueto | Milwaukee | 175.1 |
| Zach Eflin | Chicago | 173.1 |
| Dylan Bundy | Milwaukee | 170 |
| Ryan Yarbrough | El Paso | 169.2 |
| Mike Fiers | Chicago | 169 |
| Adrian Houser | Chicago | 165 |
| Sonny Gray | Peculiar | 160 |
| Nathan Eovaldi | El Paso | 146 |
| Luis Castillo | Peculiar | 141.1 |