| Player | Team | SO |
|---|---|---|
| Shane Bieber | Peculiar | 369 |
| Trevor Bauer | Peculiar | 343 |
| Carlos Carrasco | Peculiar | 280 |
| Sonny Gray | Peculiar | 259 |
| Zack Greinke | Wisc. Rapids | 254 |
| Zach Eflin | Chicago | 253 |
| Frankie Montas | Wisc. Rapids | 233 |
| Luis Castillo | Peculiar | 215 |
| Hyun Jin Ryu | Wisc. Rapids | 198 |
| Dylan Bundy | Milwaukee | 193 |
| Aaron Civale | El Paso | 184 |
| Anibal Sanchez | Wisc. Rapids | 183 |
| Adrian Houser | Chicago | 173 |
| Chris Bassitt | Chicago | 169 |
| Devin Williams | Peculiar | 169 |
| Johnny Cueto | Milwaukee | 157 |
| Charlie Morton | Wisc. Rapids | 157 |
| Martin Perez | Chicago | 152 |
| Antonio Senzatela | El Paso | 148 |
| Jack Flaherty | Milwaukee | 147 |