| Player | Team | L |
|---|---|---|
| Frankie Montas | Wisc. Rapids | 17 |
| Anibal Sanchez | Wisc. Rapids | 16 |
| Aaron Civale | El Paso | 15 |
| Zach Eflin | Chicago | 15 |
| Ryan Yarbrough | El Paso | 14 |
| John Means | El Paso | 13 |
| Antonio Senzatela | El Paso | 13 |
| Mike Fiers | Chicago | 13 |
| Martin Perez | Chicago | 13 |
| Zack Greinke | Wisc. Rapids | 13 |
| Hyun Jin Ryu | Wisc. Rapids | 12 |
| Brett Anderson | Milwaukee | 12 |
| Chris Bassitt | Chicago | 11 |
| Nathan Eovaldi | El Paso | 10 |
| Chi Chi Gonzalez | Chicago | 9 |
| Adrian Houser | Chicago | 9 |
| Trevor Bauer | Peculiar | 9 |
| Charlie Morton | Wisc. Rapids | 8 |
| Jack Flaherty | Milwaukee | 8 |
| Alex Cobb | Milwaukee | 8 |