| Player | Team | R |
|---|---|---|
| Anibal Sanchez | Wisc. Rapids | 167 |
| Frankie Montas | Wisc. Rapids | 161 |
| Austin Voth | Burlington | 151 |
| Braxton Garrett | Oak Lawn | 150 |
| German Marquez | Clinton | 148 |
| Trevor Williams | Amarillo | 148 |
| Logan Webb | Amarillo | 148 |
| Kyle Freeland | Monet | 147 |
| Kyle Gibson | Detroit | 144 |
| Ryan Castellani | Burlington | 139 |
| Aaron Nola | Burlington | 132 |
| Tanner Roark | Detroit | 131 |
| Seth Lugo | Amarillo | 131 |
| Aaron Civale | El Paso | 130 |
| Antonio Senzatela | El Paso | 126 |
| Asher Wojciechowski | Phoenix | 126 |
| Rick Porcello | Phoenix | 124 |
| Jake Odorizzi | Amarillo | 122 |
| Mike Minor | Connecticut | 120 |
| Patrick Corbin | Brooklyn | 118 |